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Individuals may develop serious infections at least every 3- 4 years

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In this work, we used a combination of biophysical techniques and cryo-electron microscopy (Cryo-EM), showing that human CBS full-length protein polymerises as a filament adopting two very different morphologies dependent on SAM binding and that polymerisation plays a role in both enzyme activation and stability

10.1016/j.ynstr.2023.100533 426 TankouS

NADPH oxidase is dormant in resting cells, but becomes activated by inflammatory cytokines and environmental pollutants