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Pregnenolone can either modulate signaling pathways itself or undergo further metabolism to form other steroid hormones, including progesterone, aldosterone, cortisol, and testosterone

Further research, including clinical trials, is needed to establish the effectiveness of these drugs in reducing renal tubular apoptosis and their effect on overall kidney function and disease progression

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Rocz Panstw Zakl Hig 66(1):6167 Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F (2014) Gender differences in the relationship between serum zinc concentration and metabolic syndrome