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129,130 These proteins are typically expressed during embryogenesis but become re-expressed in cancers while remaining largely silent in adult tissues, making them ideal targets for TCR-based and peptide-based immunotherapies, 129,131,132 Cryptic and noncanonical antigens constitute a class of tumor-associated peptides that arise from nontraditional genomic and transcriptomic regions, 133,134,135,136 Recent immunopeptidomic and translatome profiling studies have confirmed that cryptic peptides are endogenously processed and presented on MHC class I molecules across a variety of malignancies, including glioblastoma, melanoma, acute myeloid leukemia (AML), and pancreatic ductal adenocarcinoma (PDAC)

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