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Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

Often no

But they do matter

Atherosclerosis and disc degeneration/low-back pain--a systematic review

Because this phase typically peaks and begins transitioning into the remodeling phase around the 21-to-30-day mark, a 4-week administration window provides the necessary stimulus exactly when the cellular machinery is most active [3, 5]