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Since all the fragments crystallized in subpocket C contained HEPE moiety with an additional polar substituent, it was tempting to think that a similar polar moiety should be placed in subpocket C

However, in vitro -syn showed no inhibitory function on the activity of PLD

Almost all antioxidants have the potential to act as prooxidants in certain concentrations, which trigger different cell death pathways mediated through enhanced ROS production [56, 57]

TGF-beta 1 Targets Smad, P38 MAPK, and PI3K/Akt Signaling Pathways to Induce PFKFB3 Gene Expression and Glycolysis in Glioblastoma Cells

Treatment options include medications, physical therapy, orthotic devices, and, in severe cases, surgery