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Glutathione 84 , guanosine 85 , L-glutamic acid 86 , and PPARGC1A (PGC-1) are also involved in the depolarization of the mitochondrial membrane 56,87,88,89 and the density of mitochondrial cristae 90

The term intracellular signaling domain is thus meant to include any truncated portion of the intracellular signaling domain sufficient to transduce the effector function signal

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