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Psychopharmacology 159 :379-387

injected animals with the dsRNA of a target gene (experimental group)

Subsequently, Cys and Glu are conjugated by -glutamylcysteine synthetase (-GCS) to form -glutamylcysteine (-GC), which is finally combined with glycine by glutathione synthetase (GS) to produce GSH ( Accumulating evidence has uncovered two additional parallel pathways that act as critical regulators of ferroptosis