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Abstract Oxidative stress is one of the key factors that leads to red blood cells (RBCs) aging, and impairs their biomechanics and oxygen delivery

Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]

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The induction of CYP2E1 can stimulate the transport of reduced NADH to the mitochondria, which increases electron leakage from the hepatocyte mitochondrial respiratory chain and ROS generation