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Psychiatry 7 , e1137 (2017)

In practice it is sold domestically only as an unregulated "research chemical" labeled not for human consumption, meaning purity, sterility, and labeled concentration are not verified by any regulatory body

Increasing age Having family members with vein problems Hormonal changes during puberty, pregnancy, and menopause, or from birth control pills Increased amount of blood and pressure of the expanding uterus during pregnancy Obesity, leg injury, prolonged standing, and other things that weaken vein valves Why do varicose veins and spider veins appear

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