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Serum testosterone concentrations predict development of hyperglycaemia in population studies ( in vitro , androgen excess induces peripheral insulin resistance and pancreatic -cell insulin hypersecretion in both female human and mouse cell culture models, predisposing to onset of -cell failure and T2DM (Roland et al., 2010), while locally generated androgens in female adipose tissue may drive de novo lipogenesis and adipocyte hypertrophy (OReilly et al., 2017)

Advancements in muco-protective strategies and drug delivery systems are paving the way for new therapeutic opportunities

The GH-stimulating activity was essentially a discovery

The combination is tested for a synergizing effect on hormone release

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