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Description

Acting as molecular chaperones, Hsps regulate protein folding and activity, refolding proteins that have been misfolded or aggregated (Zeng et al., 2021)

Fully supported conclusions include that NTFs (especially GDNF and BDNF) can promote mitochondrial biogenesis, improve ETC function, regulate fission/fusion balance, enhance mitophagy, and inhibit apoptosis by regulating molecules such as PGC-1 and NRF1/2

Individual sites of ROS production in mitochondrial microdomains are linked to distinct diseases which further highlights the variation in local ROS production 6

Primary Handling Editor: Jennifer Sargent, in collaboration with the Nature Medicine team

Institute for Molecular Bioscience Student Symposium , Brisbane, QLD, Australia, 12 July 2024

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