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When a dissection flap extends proximally into the aortic root, it disrupts the valvular commissures and causes severe dilation, resulting in acute aortic regurgitation from a stretched aortic anulus

Yu S, Wang H, Yang L, Yan Y, Cai Q, Ma D, Jiang L, Gao Z, Yu Z, Xia Z

Phytochemistry 72(13):15311537

doi: 10.1074/mcp.M400221-MCP200 216 WalshAJCookRSManningHCHicksDJLafontantAArteagaCLet al

Although many factors have been shown to sustain ESC populations, little is known regarding cell surface receptor activation required for ESC self-renewal