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In this study, we also investigated the impact of modulating serine metabolism on IFN--driven inflammatory responses in keratinocytes and found that SHIN1 efficiently inhibited this pathogenic pathway, reducing the expression of CXCL9, CXCL10, CCL2, CCL5, IL-6, and HLA-DR

Both drug therapies significantly reduced levels of oxidized glutathione (GSSG), 8-hydroxy-2-deoxyguanosine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), while amlodipine also reduced 13-hydroxy octadecadienoic acid (13-HODE) levels

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