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[23] Antivitamin B 12 compounds (often synthetic B 12 analogues) not only have no vitamin action, but also actively interfere with the activity of true vitamin B 12

The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo

In the body, it is transformed into both bioactive coenzyme forms: methylcobalamin and adenosylcobalamin