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Ye P, Li L, Richards RG, DiAugustine RP, DErcole AJ: Myelination is altered in insulin-like growth factor-I null mutant mice

It addresses five hallmarks of aging at once: telomere maintenance, epigenetic regulation, antioxidant defense via Nrf2, immune recalibration, and circadian rhythm restoration

doi: 10.1002/bmc.555

Subsequent studies have identified a therapeutic window for RvE1 after AMI: treatment within 17 days improves cardiac function, whereas administration between 7 and 14 days may suppress angiogenesis and delay recovery [82]