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First, the molecular trigger specificity of oxalate-induced ferroptosis in renal tubular cells is undefinedhow oxalate precisely initiates the synergistic dysregulation of iron uptake (TFR1), lipid metabolism (ACSL4), and antioxidant defense (GPX4/SLC7A11) remains elusive, with no clarity on upstream signaling molecules or post-translational modifications that link oxalate exposure to ferroptosis machinery

Fallon MT, Storey DJ, Krishan A, et al

This is critical, as GSH is essential for T cell effector functions through its regulation of metabolic activity (Mak et al., 2017)

How to Use: Administration: For intramuscular (I M.) or intravenous (I V.) injection

10.1038/s41593-022-01221-3 218 SaitoY