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Additionally, the increase in hemichannel activation due to an increase in pro-inflammatory cytokines [e.g., tumor necrosis factor- (TNF-) and interleukin-1 (IL-1)] in primary cell cultures and mice results in an increase in the release of various ions (i.e., K + , Ca 2+ ) and gliotransmitters (i.e., ATP, glutamate) into the extracellular space, further disrupting homeostasis and possibly contributing to neuronal death (Retamal et al., 2007

98,99,100,101 A systematic meta-analysis that included 13 studies showed that the KD not only guarantees the basic supply of nutrients but also maintains a negative balance of energy, thereby decreasing the fluctuation and reduction of insulin secretion caused by reduced carbohydrate intake as well, which eventually leads to increased insulin sensitivity

Another SLC39A family member, SLC39A14, is closely related to SLC39A8, as evidenced by common structural features, such as three noncoding exons 211

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Achkor et al