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These methods can involve: (1) reassembling (&/or subjecting to one or more directed evolution methods described herein) at least first and second forms of a nucleic acid which comprises a gene that encodes an inhibitor of a CTL immune response, wherein the first and second forms differ from each other in two or more nucleotides, to produce a library of recombinant CTL inhibitor nucleic acids

Visualization: Hiroyuki Arai

& Coppens, I

This cell cycle inhibition is further supported by its ability to induce mitotic catastrophe and G2/M phase arrest in cervical cancer (HeLa) cells

This suggests that the final approved dosing schedule (if and when retatrutide receives approval) may offer more flexibility than the Phase 2 protocol