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Several tissues were harvested, shock-frozen and stored at 80 C until further processing

Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Ravares R, et al

The peptides mechanisms primarily support active wound healing processes

Notably, MDSC-depleting anti-DR5 antibody MD51 synergizes with immune checkpoint inhibitors such as anti-PD-L1, depletes M-MDSCs with high DR5 expression via TRAIL-mediated apoptosis, and reduces tumor infiltration without affecting T cells or DCs, leading to significantly improved tumor suppression and durable immunological memory in syngeneic models of gastric and colon cancer (93)