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Activated caspase-1 enables the N-terminal sequence of cleaved gasdermin D (GSDMD) to bind to the cell membrane to produce membrane pores, leading to cell pyroptosis and release of a large number of inflammatory factors (152)

Tissue blocks were cryosectioned on a CryoStar NX70 cryostat (ThermoScientific)

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Earlobe repair surgery is generally safe, but potential complications may include infection, bleeding, scarring, and allergic reactions to anesthesia