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NAD + and NAD + -related metabolites, NADH, NADP + and NADPH, are crucial in energy metabolism, DNA repair, epigenetic modifications, inflammation and circadian rhythms (Xie et al

Introduction Colorectal cancer (CRC) is the third most frequent cancer, with nearly 1.89 million new cases diagnosed in 2020, and the second most common cause of cancer-related death ( Within the same patient or even the same tumor, multiple mechanisms of drug resistance can coexist, and this is generally thought to be due to rare, stochastic genetic alterations ( in vitro from commercial cell lines or in vivo from patient-derived xenografts, and they present across various kinds of tumors ( Drug-tolerant persister cells may eventually acquire irreversible resistance-conferring genetic mutations and bona fide drug-resistance mechanisms to avoid eradication by prolonged lethal exposures ( 2+ ), can create ROS by participating in the Fenton reaction, thereby triggering ferroptosis ( In this study, we followed a previously established procedure ( in vitro

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