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Enzyme kinetics Michalis-Menten constant ( Km ) was deduced from the Linewear-Burk plot construction utilizing (0.1 2 mM) CDNB as substrate at 25 C

7 Dosages used in the studies ranged from 400 to 2000 mg per day

doi: 10.1111/j.1365-2133.2007.08364.x [DOI] [PubMed] [Google Scholar] 27.Ghersetich I, Troiano M, Brazzini B, Arunachalam M, Lotti T

In contrast, it would appear that the neurologic effects of cobalamin deficiency are due to metabolic disturbances unrelated to purine synthesis because the neurologic deficits may develop independently of the hematologic abnormalities, and folate supplementation will not prevent or reverse these deficits

Liverani, E