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By thoroughly understanding resistance mechanisms, clinicians can develop more precise treatment plans based on patients specific molecular characteristics, thereby significantly improving treatment outcomes

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Whereas the participants who took the fish oil supplement had biomarker profiles that were cardioprotective, the participants who took the placebo had biomarker profiles associated with inflammation and cardiovascular disease

In addition to transcriptional priming, a study focusing on chemotolerance in triple-negative breast cancer revealed epigenetic priming, in which the repressive histone mark H3K27me3 dictates cell fate trajectory upon treatment 50