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Most of this traces back to a 2012 US National Toxicology Program (NTP) study where hairless mice coated in Retinyl Palmitate cream and exposed to UV light developed skin tumors faster

Lachowiez CA, Reville PK, Kantarjian H, Jabbour E, Borthakur G , Daver N, Issa G, Furudate K, Tanaka T, Pierce S, Tang G, Patel KP, Medeiros J, Abbas HA, Haddad F, Hammond D, Short NJ, Maiti A, Yilmaz M, Sasaki K, Takahashi K, Pemmaraju N, Konopleva M, Garcia-Manero G, Ravandi F, Kadia TM, Loghavi S, DiNardo CD

Phase III transporters, including members of ATP-binding cassette (ABC) transporter families such as P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), breast cancer resistance protein, and bile salt export pump, regulate drug efflux, bile acid handling, and intracellular substrate availability 6

Gordon CL, Halton JM, Atkinson SA, Webber CE