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Studies have identified distinct protein signatures in EVs from AD patients biofluids, such as serum and cerebrospinal fluid, highlighting candidate molecules such as alpha-1-antichymotrypsin (AACT) and C4b-binding protein alpha chain (C4BP) that bind A and may influence disease progression [89]

doi: 10.1007/s00709-019-01351-9 37 LiuY.von WirnN

Current in vivo and mechanistic data support the hypothesis that piperine may sensitize cancer cells to ferroptosis-like cell death, although direct confirmation of canonical ferroptosis markers, such as GPX4 inhibition, system Xc - suppression, or iron dependency, remains limited

Seifar, F., Dinasarapu, A