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Anti-inflammatory nutrients and obesity-associated metabolic-inflammation: state of the art and future direction

Diabetic cardiomyopathy, a unique type of cardiac damage, exhibits abnormal myocardial structures independent of hypertension, coronary artery disease, valvular heart disease or other known precipitating factors for heart failure (Rubler et al., 1972

Melatonin can alleviate glomerular hypertrophy and excessive accumulation of mesangial matrix, delay the progression of DKD, and improve renal dysfunction by activating the AMPK/SIRT1 pathway in both the STZ-induced DKD model and the NEK-52E cell treated with HG

doi: 10.1111/odi.12858 92 KemperK