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Participants treated with safinamide (50 mg/day or 100 mg/day) experienced significant improvements in ON time compared to placebo, with mean increases of 1.3 hours in the safinamide groups versus 0.7 hours in the placebo group (50 mg/day, p = 0.022

Su, X.-C

Furthermore, O 2 molecules can be converted from the high-spin state ( 3 O 2 ) to the low-spin state ( 1 O 2 ) by surface plasmon resonance of metals (such as Pt, Au)

These include suppression of tumor necrosis factor-alpha (TNF-)-mediated apoptosis and induced interleukin (IL)1 production

Apurinic/Apyrimidinic (AP) sites in the brain, spinal cord, and brainstem of ALS patients are vulnerable to DNA lesions induced by free radicals and intermediates (Kim et al., 2020)