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Fine-tuning of NO diffusion from the endothelium to the smooth muscle cell is controlled by regulation of its Fe 2+ /Fe 3+ redox equilibrium (172)

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Importantly, mitochondrial content was restored when HIF1 or HIF2 were simultaneously inactivated with Vhl , demonstrating that loss of mitochondrial abundance in Vhl -deficient renal epithelium can be entirely attributed to the overactivation of both HIF1 and HIF2 isoforms (Farsijani et al., 2016)

Glutathione is conventionally recognized as a difficult-to-absorb molecule, and various delivery approaches are aimed at enhancing its bioavailability and absorption

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