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It also participates in gut-brain axis signaling and displays antitumor effects by promoting apoptosis and cell cycle arrest in malignant colonocytes, while supporting proliferation in normal colonocytes (166169)

The atrophy process can result in skeletal muscle cell apoptosis, protein degradation, fat deposition, and other pathophysiological changes

SiracusaRDAmicoRImpellizzeriDCordaroMPeritoreAFGugliandoloEet al

As these two studies only investigated two tumor cell lines from different tumor types and compared them with the normal cells from different tissues and organs, it is hard to find out whether the difference of ferroptosis regulation by hypoxia is dependent on some genes differently expressed in tumor and normal cells

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