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This approach addresses challenges like rapid degradation and systemic toxicity by releasing cytokines only at the desired site (89, 90)

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Pegaptanib (Macugen) selectively binds to a specific type of VEGF called VEGF 165, which is one of the most dangerous forms of VEGF (Chakravarthy 2006)

Then, NLRP3 together with the adaptor ASC (apoptosis-associated speck-like protein), and pro-caspase 1 will form a Caspase-1 activating complex called NLRP3 inflammasome