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Cuprizone ingestion alters mitochondria in the CNS of mice [2729, 109]

Specifically, we show that AR directly represses BCL-2 transcription via binding to multiple ARBS across the BCL-2 genomic region, especially the ARBS1 around the promoter, and castration and ARPI treatment block AR engagement to most ARBS leading to de-repression of BCL-2 transcription

Siddiqua TJ, Akhtar E, Haq MA, et al

Important: Sterile Water for Injection must be made approximately isotonic (having a similar concentration of solutes as blood) by mixing it with a solute before intravenous administration