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These issues necessitate the development of dedicated ethical and regulatory frameworks

Serum/plasma total Se concentrations can be influenced by sex, age, smoking, water and diet Se content, dietary sources of Se (organic or inorganic), and various conditions that increase its demands or decrease its intake/utilization, leading to decreased Se concentrations (e.g., inflammation, anorexia, intestinal malabsorption syndromes, and total enteral or parenteral nutrition without adequate Se dosing) (45, 57, 75)

However, based on the large degree of renal metabolism of pramlintide, hepatic dysfunction is not expected to affect exposure

doi: 10.1038/s41598-018-36235-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 83

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