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The peptide acts as a signalling molecule that stimulates fibroblasts the cells responsible for producing and maintaining collagen to increase their synthetic activity

Secreted IL-13 from activated Th2 cells can influence the release of TGF-1 from activated macrophages through the JNK signaling pathway, regulate fibroblast proliferation and differentiation through the JNK and AKT signaling pathway as well and promote the expression of -SMA and collagen I that leads to the development of fibrosis 71

The factors may include, but are not limited to, a combination of TLR agonists and immune complexes, apoptotic cells, IL-10, prostaglandins, GPcR ligands, adenosine, dopamine (dopamine), histamine, sphingosine 1-phosphate, melanocortins, vasoactive intestinal peptide, and Siglec-9

The food you eat, the rest you get, even the stress on your mind, all of it shapes how long those results last in your body