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Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia

This drives more chondrocytes into oxidative damage and ferroptosis, thereby exacerbating the overall pathological progression of OA (Grigolo et al., 2003

Accelerating drug target inhibitor discovery with a deep generative foundation model

Glossary HHCY hyperhomocysteinemia AS atherosclerosis HCY homocysteine ECs endothelial cells NO nitric oxide ROS reactive oxygen species SAM AdoMet, S-adenosylmethionine MAT methionine adenosyltransferase ATP adenosine triphosphate SAH AdoHcy, S-adenosylhomocysteine CBS cystathionine -synthase CSE cystathionine-gamma-lyase 5-methylTHF 5-methyltetrahydrofolic acid MS methionine synthase THF tetrahydrofolate BHMT betaine-homocysteine methyltransferase DHFR dihydrofolate reductase IL interleukin TNF tumor necrosis factor NF-B nuclear factor kappa-B PAI-1 plasminogen activator inhibitor-1 SASP senescence-associated secretory phenotype NOS nitric oxide synthase ADMA asymmetric dimethylarginine DDAH dimethylarginine dimethylaminohydrolase PKC protein kinase C NADPH nicotinamide adenine dinucleotide phosphate ERS endoplasmic reticulum stress ER endoplasmic reticulum Ero-1 endoplasmic reticulum oxidoreductin-1 HIF-1 hypoxia-inducible factor-1 GPX glutathione peroxidase H 2 S hydrogen sulfide ERK extracellular regulated protein kinases miR microRNA LDL low-density lipoproteins HDL high-density lipoproteins HDL-C high-density lipoprotein cholesterol ApoA1 apolipoprotein A1 TG triglyceride TC total cholesterol LDL-C low-density lipoprotein cholesterol ox-LDL oxidized low density lipoprotein VSMCs vascular smooth muscle cells ICAM-1 intercellular adhesion molecule-1 VCAM-1 vascular adhesion molecule-1 DNMT1 DNA methyltransferase 1 EPCs endothelial progenitor cells HTL homocysteine thiolactone MetRS methionyl-tRNA synthetase PQC cellular protein quality control UPR unfolded protein response UPS ubiquitin-proteasome system ACE angiotensin-converting enzyme ANG II angiotensin II LPO lipid peroxidation Cyt C cytochrome c Bax B-cell lymphoma-2 associated X protein Bcl-2 B-cell lymphoma-2 HUVECs human umbilic vein endothelial cells GLP-1 glucagon-like peptide 1 EGCG epigallocatechin gallate SIRT1 silent information regulator 1 AMPK AMP-activated protein kinase Nano-Se nanoscale selenium HCAECs human coronary artery endothelial cells DAMPs damage-associated molecular patterns PAMPs pathogen-associated molecular patterns PRRs pattern recognition receptors ASC alanine-serine-cysteine

Oncologist 7:1419