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Closing the knowledge gaps requires a parallel advancement in our experimental and analytical capabilities: Developing artefact-free, relevant mechanistic assays: as noted, the uncritical use of conventional toxicity assays has likely generated a body of data compromised by ENM-specific artefacts

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Toxicol in Vitro 82:105368

Certain biosensing systems require multi-step operations, invasive sampling, or complicated pattern interpretation, which overshadow the benefits of point-of-care device performance

The lower glutamine levels could be due to either decreased GLS-mediated synthesis or increased glutamine utilization/uptake