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For others, their system may need a more regular top-up to maintain optimal levels

10.1016/j.tox.2019.02.011 Toxicology 78 HouW.XieY.SongX.SunX.LotzeM

Trends Endocrinol Metab (2017) 28:84354

In a study performed on 75 subjects (3 neonates, 25 infants, 25 children, and 22 adolescents), a PK model was developed from data following intravenous APAP administration (Zuppa et al., 2011)