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Use of Antioxidants During Chemotherapy and Radiotherapy Should Be Avoided

The use of objective neurophysiological measures (e.g., EEG, MRI, MEG, ABR) or biomarkers (e.g., blood or DNA sampling) may be more useful and reduce experimental variability

Interestingly, elevated pyroglutamate levels have been associated with toxic effects 37 , as its accumulation may disrupt redox homeostasis and interfere with glutamate metabolism