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It stops inflammatory genes from switching on in the first place (NF-B inhibition), a different approach from NSAIDs that block inflammation after it has already started

Find the timing that works best for your routine

Frequent missed doses do reduce effectiveness, so work on strategies to improve adherence if this becomes a pattern

J Cell Biochem

Building a MOTS-C Protocol Within a Longevity Program A MOTS-c protocol is most powerful not as a standalone intervention but as one layer of a structured longevity program that addresses mitochondrial health, metabolic flexibility, and body composition simultaneously