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If you arent responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine (called triple therapy) or adding a biologic drug such as etanercept (Enbrel), adalimumab (Humira), or infliximab (Remicade)

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Causes of Burning Sensations While nerve issues are a common cause, burning sensations may be due to other conditions affecting either the Central Nervous System (CNS) or the Peripheral Nervous System (PNS) : Central Pain Syndrome : Damage to the CNS, which includes the brain and spinal cord, may lead to chronic burning pain