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For patients with unexplained mental and motor developmental delay, seizures, recurrent acute encephalopathy, and systemic multisystem manifestations, it is important to conduct early diagnostic investigations such as cranial MRI, EEG, plasma amino acid metabolism, urine organic acid metabolism analysis, CSF metabolism, and genetic testing to clarify the diagnosis

doi: 10.1016/j.molcel.2015.02.021

Individuals with Digestive Issues: Conditions like Crohns disease, celiac disease, and gastric surgeries can hinder B12 absorption

The cross-sectional nature of this study means that no causal inferences can be made about the direction of the associations

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