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(2005) Sortilin controls intracellular sorting of brain derived neurotrophic factor to regulated secretory pathway

Jun 1 2021;12(3):777-792

When mTOR activity is elevated, it suppresses the initiation and progression of autophagy

A comprehensive literature search was conducted using the MEDLINE database (PubMed) for English-language articles published up to May 2025 using combinations of key search terms including diabetes mellitus, diabetes, neuropathy, polyneuropathy, diabetic neuropathies, peripheral neuropathy, diabetic polyneuropathy, pathophysiology, diagnosis and treatment. Articles were selected that primarily focused on DPN, with emphasis on human studies addressing the pathophysiology, clinical presentation, diagnostic approaches and therapeutic interventions