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Loss of cGAS abolished senescence phenotypes and senescence-associated -galactosidase (SA--Gal) activity, suggesting that cGAS is essential for cellular senescence (Yang et al., 2017)

This finding is surprising because asparagine supplementation does not restore the levels of other NEAAs (alanine, proline, and glutamate) or any TCA cycle intermediates (-KG, malate, and fumarate)

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