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Briefly, the major cations are potassium ( K + ) and magnesium ( Mg 2 + ), and the major anions are proteins and organic phosphates such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP)

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It may be that different shapes of metal-based NPs lead to different bioaccumulation or/and reactivity, finally resulting in the differences in toxicity ( Besides size and shape, surface chemistry is another critical factor that remarkably affects toxicity (Li et al., 2013