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Furthermore, IGF1r is a classical tyrosine kinase receptor whose activity is primarily regulated by phosphorylation [48]

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Interleukin (IL)-1b, a pro-inflammatory cytokine, was the first cytokine to be identified as enhancing HPA axis activity during an immunological response ( Natural coumarin anti-oxidant 4-methylesculetin (4-MESC) has anti-inflammatory effects on intestinal inflammation, whose pathogenesis and oxidative stress are both major contributors to it (Tanimoto et al., 2020)

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