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After vitamin B12 is released from food proteins by gastric acid and pepsin, it initially binds to haptocorrin (R-protein) in the stomach

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Recombinant OspA, BB0172-derived peptide, BbHtrA, BB0689, RevA, recombinant P66, recombinant VlsE, lipidated recombinant protein, CspZ, and protein with nanoparticles (such as ferritin, LNP) are used as vaccine candidate among included studies that showed potential efficacy against Lyme bacteria ( Table 2 )

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