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This is basic physics, not a complication

Evolving perspectives on innate immune mechanisms of IPF

Keep in mind that oral B is not well absorbed in people who truly lack intrinsic factor or have certain GI issues, which is why B is usually injected or given as a high-dose sublingual in those cases

Interestingly, NKCC1 KO mice also showed reduced satiation control to ad libitum feeding before developing overweight and a MetS-like phenotype (Rathod et al., 2023), consistent with the hypothesis that islets hormones participate in the control of food/energy intake (Woods et al., 2006)