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The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

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Molecular mechanisms driving this immune activation include toll-like receptors (TLRs) and the complement system, both of which mediate microglial responses to stressors such as elevated IOP and systemic inflammation (153)

Pharmacological inhibition of SLC7A11 significantly causes tumor regression of PDAC and eliminates MCU-driven metastasis, suggesting that SLC7A11 may be a downstream target of the MCU-Nrf2 axis

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