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Drugs such as N -acetylcysteine (NAC) and guanfacine have shown promise in alleviating symptoms of brain fog by reducing oxidative stress and improving cognitive function

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Beyond its senomorphic effects, exercise also exhibits senolytic activity by promoting autophagic clearance of senescent cells through TFEB activation and increased caspase-3-dependent apoptosis ( 4.4 Exercise enhances mitochondrial function and autophagy systems, restoring cellular quality control Mitochondrial dysfunction and autophagy impairment are major contributors to ferroptosis vulnerability in the aging brain (Wang et al., 2022b

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