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In another study, Giri et al, showed that niacin may reduce inflammation by targeting its receptor GPR09A

ROS signaling under metabolic stress: Cross-talk between AMPK and AKT pathway

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Abbreviations: GSH: glutathione, BDI: Beck Depression Inventory, HAM-D: Hamilton Depression Rating Scale, MADRS: MontgomeryAsberg Depression Rating Scale, PSS: Perceived Stress Scale, PANAS: Positive and Negative Affect Schedule

For example, aromatic anticonvulsants are metabolized by CYP (cytochrome P450 - phase I of drug metabolism) into arene-oxide metabolites, normally detoxified in the conjugation pathways (phase II of drug metabolism) into inactive metabolites by epoxide hydrolase or glutathione transferase