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Furthermore, the finding that CX3CR1-expressing stromal microglia were required for optic glioma formation in NF1-OPG mouse model established the role of microglia as essential drivers of optic gliomagenesis (93)

doi: 10.1097/00005344-199410000-00016 53 IsaacCMathorMBBarianiGPaggiaroAOHersonMRGoldenstein-SchainbergCet al

The E protein is recognized topologically to be N lumen C cyto (N-terminal ERGolgi intermediate compartment lumen and carboxy-terminal (C-terminal) cytoplasm) and involved in regulation of pumping Ca 2+ out of the ER, which may lead to activation of the cellular inflammasome, thereby enhancing the host antiviral response

The activation of CHAC1 by this pathway leads to increased apoptosis, as evidenced by its role in enhancing apoptosis markers such as TUNEL, PARP cleavage, and AIF nuclear translocation

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